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진단검사의학과

홍성근

전문분야
임상미생물, 항균제내성

교수 경력

  • 차의과학대학교

진료 경력

  • 現 차의과학대학교 분당차병원 진단검사의학과 교수

학력사항

  • 연세대학교 의과대학 졸업
  • 연세대학교 대학원 의학 석사
  • 연세대학교 대학원 의학 박사

학회/연구/Postdoctorial Fellowship/수상경력

  • 학회
  • 대한진단검사의학회 평의원
  • 대한임상미생물학회 평의원
  • 대한의료관련감염관리학회 평의원
  • American society for microbiology 회원
  • European Society of Clinical Microbiology and Infectious Diseases 회원

  • Postdoctorial Fellowship
  • Research fellow, Creighton University, Omaha, Nebraska, USA (2005.09~2006.08)

  • 기타
  • 세균내성연구소 운영위원
  • 검사실 신임위원회 심사원
진단검사의학과 이달의 논문

엑소좀 DNA와 드롭렛 디지털 PCR을 이용한 결핵 진단의 새로운 접근

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
  • 언론기사·영상
  • 논문
더보기
  1. SARS-CoV2 Mutation Detection Experience Using PowerChek SARS-CoV-2 S-gene Mutation Detection Kit, Annals of Clinical Microbiology, 2023-08, (국내)KCI
  2. Cost-Effectiveness Analysis of Three Diagnostic Strategies for the Detection of EGFR Mutation inAdvanced Non-Small Cell Lung Cancer, Annals of Laboratory Medicine, 2023-06, (국외)SCI
  3. ALX148에 의한 수혈전검사 간섭현상을 적혈구 동종흡착을 통해해결한 2예, 대한수혈학회지, 2023-04, (국내)KCI
  4. Human iPSC-derived neural precursor cells differentiate into multiple cell types to delay disease progression following transplantation into YAC128 Huntington's disease mouse model, Cell proliferation, 2021-05, (국외)SCI
  5. "First Identification of IMP-1 Metallo-β-Lactamase in Delftia tsuruhatensis Strain CRS1243 Isolated From a Clinical Specimen", Annals of Laboratory Medicine, 2021-01, (국내)SCIE
  6. Potentiation of cord blood cell therapy with erythropoietin for children with CP: a 2 ?2 factorial randomized placebo-controlled trial, Stem Cell Research & Therapy, 2020-11, (국외)SCI
  7. Intracerebral transplantation of HLA-homozygous human iPSC-derived neural precursors ameliorates the behavioural and pathological deficits in a rodent model of ischaemic stroke, Cell proliferation, 2020-07, (국외)SCIE
  8. Differential contributions of sarcomere and mitochondria-related multigene variants to the endophenotype of hypertrophic cardiomyopathy, Mitochondrion, 2020-04, (국외)SCIE
  9. The First Korean Case of High-Molecular-Weight Kininogen Deficiency, With a Novel Variant, c.488delG, in the KNG1 Gene, Annals of Laboratory Medicine, 2019-11, (국내)SCIE
  10. A novel approach for tuberculosis diagnosis using exosomal DNA and droplet digital PCR, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2019-11, (국외)SCI
  11. Prognostic utility of ADAMTS13 activity for the atypical hemolytic uremic syndrome (aHUS) and comparison of complement serology between aHUS and thrombotic thrombocytopenic purpura, Blood Research, 2019-08, (국내)SCOPUS
  12. 호주 적혈구 적정 재고량 계산 공식의 국내 적용 경험, 대한수혈학회지, 2018-07, (국내)KCI
  13. Repurposing the Cord Blood Bank for Haplobanking of HLA-Homozygous iPSCs and Their Usefulness to Multiple Populations, Stem cells (Dayton, Ohio), 2018-06, (국외)SCI
  14. The 2016 WHO versus 2008 WHO Criteria for the Diagnosis of Chronic Myelomonocytic Leukemia, Annals of Laboratory Medicine, 2018-04, (국외)SCIE
  15. Rapid, Reliable, and Inexpensive HLA-B*58:01 Detection Method Using DNA Binding Dye-based Duplex Allele-specific Melting Curve Analysis., Annals of clinical and laboratory science, 2018-03, (국내)SCI
  16. HLA-A*02:687, a novel allele identified by sequence-based typing in cord blood from a Korean woman, Tissue antigens, 2017-07, (국외)SCI
  17. Quality comparison of umbilical cord blood cryopreserved with conventional versus automated systems, Cryobiology, 2017-07, (국외)SCI
  18. 임신 여성에서 B군 사슬알균 검사[실시간 중합효소연쇄반응법]의 진단정확성과 검출률: 체계적 문헌고찰과 메타분석, 대한임상미생물학회지 , 2017-06, (국내)KCI
  19. A case of atypical hemolytic uremic syndrome associated with the c.1273C＞T mutation in the complement C3 gene, Blood Research, 2016-09, (국내)SCOPUS
  20. Levofloxacin Efflux and smeD in Clinical Isolates of Stenotrophomonas maltophilia., Microbial drug resistance (Larchmont, N.Y.), 2016-05, (국외)SCI
  21. HLA-A*33:102, a novel allele identified by sequence-based typing in cord blood from a Korean woman, Tissue antigens, 2016-03, (국외)SCI
  22. Human umbilical cord blood mononuclear cells and chorionic plate-derived mesenchymal stem cells promote axon survival in a rat model of optic nerve crush injury, International journal of molecular medicine, 2016-02, (국외)SCI
  23. In Vitro Synergistic Effects of Antimicrobial Combinations on Extensively Drug-Resistant Pseudomonas aeruginosa and Acinetobacter baumannii Isolates, Annals of Laboratory Medicine, 2015-12, (국내)SCIE
  24. Establishing Quality Control Ranges for Antimicrobial Susceptibility Testing of Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus: A Cornerstone to Develop Reference Strains for Korean Clinical Microbiology Laboratories, Annals of Laboratory Medicine, 2015-08, (국내)SCIE
  25. HLA-B*59:09, a novel allele identified by sequence-based typing in a cord blood donated by a Korean woman, Tissue antigens, 2015-06, (국외)SCI
  26. Involvement of Immune Responses in the Efficacy of Cord Blood Cell Therapy for Cerebral Palsy, Stem cells and development, 2015-05, (국외)SCI
  27. Assessment of cell viability, early apoptosis, and hematopoietic potential in umbilical cord blood units after storage, Transfusion, 2015-02, (국외)SCI
  28. Combined Use of the Modified Hodge Test and Carbapenemase Inhibition Test for Detection of Carbapenemase-Producing Enterobacteriaceae and Metallo-β-Lactamase-Producing Pseudomonas spp., Annals of Laboratory Medicine, 2014-12, (국내)SCIE
  29. The sul1 Gene in Stenotrophomonas maltophilia With High-Level Resistance to Trimethoprim/Sulfamethoxazole, Annals of Laboratory Medicine, 2014-12, (국내)SCIE
  30. A 2-month-old boy with hemolytic anemia and reticulocytopenia following intravenous immunoglobulin therapy for Kawasaki disease: a case report and literature review, Korean Journal of Pediatrics, 2014-10, (국내)SCOPUS
  31. Clonality and Resistome Analysis of KPC-Producing Klebsiella pneumoniae Strain Isolated in Korea Using Whole Genome Sequencing, BioMed research international, 2014-06, (국외)SCIE
  32. 국내 중환자실 환자에서 분리된 세균의 항균제 내성, 병원감염관리, 2014-05, (국내)기타
  33. Estimation of size of cord blood inventory based on high-resolution typing of HLAs., Bone marrow transplantation, 2014-03, (국외)SCI
  34. First Outbreak of KPC-2-Producing Klebsiella pneumoniae Sequence Type 258 in a Hospital in South Korea, Journal of clinical microbiology, 2013-08, (국외)SCI
  35. Novel nonsense GNAS mutation in a 14-month-old boy with plate-like osteoma cutis and medulloblastoma, The Journal of dermatology, 2013-08, (국외)SCIE
  36. Assessment of Cell Viability in Umbilical Cord Blood by Using 7-AAD/annexin V Dual Staining, Laboratory Medicine Online, 2013-05, (국내)KCI후보
  37. HLA-A, -B and -DRB1 polymorphism in Koreans defined by sequence-based typing of 4128 cord blood units, International journal of immunogenetics, 2013-05, (국외)SCI
  38. Allogenic umbilical cord blood therapy combined with erythropoietin for patients with severe traumatic brain injury: Three case reports, Restorative neurology and neuroscience, 2013-02, (국외)SCIE
  39. Current routine practice and clinico-pathological characteristics associated with acute promyelocytic leukemia in Korea, Blood Research, 2013-02, (국내)KCI
  40. Characterization of anti-factor VIII antibody in a patient with acquired hemophilia A, Blood Research, 2013-02, (국내)KCI
  41. Umbilical Cord Blood Therapy Potentiated with Erythropoietin for Children with Cerebral Palsy: A Double-blind, Randomized, Placebo-controlled Trial, Stem cells (Dayton, Ohio), 2012-11, (국외)SCI
  42. Antimicrobial Susceptibility of Stenotrophomonas maltophilia Isolates from Korea, and the Activity of Antimicrobial Combinations against the Isolates, Journal of Korean medical science, 2012-11, (국내)SCI
  43. Identification of two novel HLA alleles: HLA-DRB1*12:03:03 and HLA-DRB1*13:143, Tissue antigens, 2012-11, (국외)SCI
  44. A case of transfusion-related acute lung injury induced by anti-human leukocyte antigen antibodies in acute leukemia, The Korean Journal of Hematology, 2012-10, (국내)KCI
  45. Synergistic killing effect of imatinib and simvastatin on imatinib-resistant chronic myelogenous leukemia cells, Anti-cancer drugs, 2012-09, (국외)SCI
  46. HLA-B*40:179, a novel allele identified by sequence-based typing in cord blood from a Korean woman, Tissue antigens, 2012-08, (국외)SCI
  47. Multiplex PCR for Rapid Detection of Genes EncodingClass A Carbapenemases, Annals of Laboratory Medicine, 2012-07, (국내)SCIE
  48. A Trp33Arg mutation at exon 1 of the MYH9 gene in a Korean patient with May-Hegglin anomaly., Yonsei medical journal, 2012-06, (국내)SCIE
  49. High prevalence of vitamin D insufficiency or deficiency in young adolescents in Korea, European journal of pediatrics, 2012-04, (국외)SCI
  50. HLA-A*02:328, a novel allele identified by sequence-based typing in cord blood from a Korean woman., Tissue antigens, 2012-04, (국외)SCI
  51. Molecular Identification of a New Splicing Variant of the MLL - MLLT11 Fusion Transcript in an Adult with Acute Myeloid Leukemia and t(1;11)(q21;q23), Acta haematologica, 2012-03, (국외)SCI
  52. Acute promyelocytic leukemia with trisomy 8 showing normal PML-RARA FISH signal patterns: diagnostic application of long-distance polymerase chain reaction in molecularly discrepant leukemia cases, Annals of hematology, 2012-02, (국외)SCI
  53. HLA-A*33:25, a novel allele identified by sequence-based typing, is a well-documented allele in Koreans, Tissue antigens, 2012-02, (국외)SCI
  54. A Rapid Long PCR-Direct Sequencing Analysis for ABO Genotyping, Annals of clinical and laboratory science, 2011-12, (국외)SCI
  55. The Levels of Pro-Inflammatory Factors Are Significantly Decreased in Cerebral Palsy Patients Following an Allogeneic Umbilical Cord Blood Cell Transplant, International Journal of Stem Cells, 2011-12, (국내)기타
  56. T-cell Acute Lymphoblastic Leukemia Associated with Complex Karyotype and SET-NUP214 Rearrangement: A Case Study and Review of the Literature, Annals of clinical and laboratory science, 2011-11, (국외)SCI
  57. Genomic analysis of a four-way t(4;11;22;10) associated with MLL-AF4 in an adult acute lymphoblastic leukemia, Annals of hematology, 2011-10, (국외)SCI
  58. Antimicrobial Susceptibility of Stenotrophomonas maltophilia Isolates from a Korean Tertiary Care Hospital, Yonsei medical journal, 2011-08, (국내)SCIE
  59. Trends in Antimicrobial Resistance of Neisseria gonorrhoeae Isolated From Korean Patients From 2000 to 2006, Sexually transmitted diseases, 2011-07, (국외)SCI
  60. A novel splice-site mutation c.42-2A>T (IVS1-2A>T) of SERPINC1 in a Korean family with inherited antithrombin deficiency., Blood coagulation and fibrinolysis : an international journal in haemostasis and thrombosis, 2011-07, (국외)SCI
  61. Emergence of Escherichia coli Sequence Type ST131 Carrying both the blaGES-5 and blaCTX-M-15 Genes, Antimicrobial agents and chemotherapy, 2011-06, (국외)SCI
  62. 복강경 기구의 재사용에 대한 임상적 의의, 대한내시경복강경외과학회지, 2011-06, (국내)KCI
  63. Acquisition of extensive drug-resistant Pseudomonas aeruginosa among hospitalized patients: risk factors and resistance mechanisms to carbapenems, The Journal of hospital infection, 2011-05, (국외)SCI
  64. Characterization of antiphospholipid antibodies in chronic hepatitis B infection, The Korean Journal of Hematology, 2011-02, (국내)KCI
  65. MTHFR C677T polymorphism as a risk factor for vascular calcification in chronic hemodialysis patients, Journal of Korean medical science, 2010-12, (국내)SCI
  66. A Novel Mutation of the WAS gene in a Patient with Wiskott- Aldrich Syndrome Presenting with Recalcitrant Viral Warts, Journal of dermatological science, 2010-11, (국외)SCI
  67. Early Detection of Preeclampsia Using Inhibin A and Other Second-Trimester Serum Markers, Fetal diagnosis and therapy, 2010-11, (국외)SCI
  68. 한국인 산모에서 다운증후군 산전선별검사로서의 통합선별검사의 유용성 평가, Laboratory Medicine Online, 2010-10, (국내)KCI후보
  69. 냉동보관 전 제대혈 세포의 생존율 평가, 대한수혈학회지, 2010-08, (국내)KCI후보
  70. A novel insertion mutation 718dupG in the PROC gene in a Korean thrombophilic family, Thrombosis research, 2010-07, (국외)SCI
  71. Evaluation of 28 Human Embryonic Stem Cell Lines for Use as Unrelated Donors in Stem Cell Therapy: Implications of HLA and ABO Genotypes, Cell transplantation, 2010-06, (국외)SCI
  72. Characteristics of clinical isolates of Acinetobacter genomospecies 10 carrying two different metallo-b-lactamases, International journal of antimicrobial agents, 2010-05, (국외)SCI
  73. Clathrin Assembly Lymphoid Myeloid Leukemia-AF10-positive Acute Leukemias: A Report of 2 Cases with a Review of the Literature, 대한진단검사의학회지, 2010-03, (국내)SCIE
  74. A novel insertion mutation 718dupG in the PROC gene in a Koreanthrombophilic family, Thrombosis research, 2010-02, (국외)SCI
  75. Evaluation of modified non-overt DIC criteria on the prediction of poor outcome in patients with sepsis, Thrombosis research, 2009-12, (국외)SCI
  76. In vivo selection of carbapenem-resistant Klebsiella pneumoniae by OmpK36 loss during meropenem treatment, Diagnostic microbiology and infectious disease, 2009-08, (국외)SCI
  77. Escherichia coli, Klebsiella pneumoniae 및 Proteus mirabilis에서 플라즈미드매개성 AmpC B-lactamase를 검출하는 3가지 표현형 검사법 비교, 대한진단검사의학회지, 2009-08, (국내)SCIE
  78. 임신합병증 예측에 있어 다운증후군 통합 선별검사 지표의 의의, Journal of Genetic Medicine, 2009-06, (국내)기타
  79. 만성폐쇄성폐질환 급성 악화로 입원한 환자의 세균성 원인, 대한내과학회지, 2009-03, (국내)KCI
  80. Simple Use of the Suppository Type Povidone-Iodine Can Prevent Infectious Complications in Transrectal Ultrasound-Guided Prostate Biopsy, Advances in Urology, 2009-03, (국외)기타
  81. 임상 검체에서 단독으로 분리된 Leclercia adecarboxylata 2예, 감염과화학요법, 2009-02, (국내)KCI후보
  82. Spread of Serratia marcescens coharboring aac(6')-Ib-cr, bla CTX-M, armA, and bla OXA-1 carried by conjugative IncL/M type plasmid in Korean hospitals, Microbial Drug Resistance, 2009-01, (국외)SCI
  83. Prevalence and spread of integron–IS26 in imipenem-resistant Acinetobacter baumannii clinical isolates in South Korea , International journal of antimicrobial agents, 2009-01, (국외)SCI
  84. Effect of methylenetetrahydrofolate reductase and thymidylate synthase enhancer region polymorphisms on the risk of idiopathic recurrent spontaneous abortion in a Korean population, Fertility and sterility, 2008-09, (국외)SCI
  85. Surveillance of Community-Based Reservoirs Reveals the Presence of CTX-M, Imported AmpC, and OXA-30 beta-lactamases in Urine Isolates of Klebsiella pneumoniae and Escherichia coli in a US Community, Antimicrobial agents and chemotherapy, 2008-07, (국외)SCI
  86. A novel bla(CTX-M-14) gene-harboring complex class 1 integron with an In4-like backbone structure from a clinical isolate of Escherichia coli, Diagnostic microbiology and infectious disease, 2008-06, (국외)SCI
  87. 정상 간기능 수치를 보이는 비알코올지방간 환자의 임상특징, 대한소화기학회지, 2008-05, (국내)KCI
  88. In vitro activity of tigecycline against multidrug-resistant Acinetobacter baumannii and selection of tigecycline-amikacin synergy, Antimicrobial agents and chemotherapy, 2008-05, (국외)SCI
  89. Newer β-Lactamases: Clinical and Laboratory Implications, Part II, Clinical microbiology newsletter , 2008-04, (국외)SCOPUS
  90. Newer β-Lactamases: Clinical and Laboratory Implications, Part I, Clinical microbiology newsletter , 2008-04, (국외)SCOPUS
  91. Occult hepatitis B virus infection in pregnant woman and its clinical implication, Liver international : official journal of the International Association for the Study of the Liver, 2008-01, (국외)SCI
  92. Frequency of Pro475Ser polymorphism of ADAMTS13 gene and its association with ADAMTS-13 activity in Korean population, Yonsei medical journal, 2007-12, (국내)SCIE
  93. Convenient test using a combination of chelating agents for detection of metallo-beta-lactamases in the clinical laboratory. , Journal of clinical microbiology, 2007-06, (국외)SCI
  94. Comparison of Phoenix and VITEK 2 extended-spectrum-beta-lactamase detection tests for analysis of Escherichia coli and Klebsiella isolates with well-characterized beta-lactamases. , Journal of clinical microbiology, 2007-06, (국외)SCI
  95. Antimicrobial resistance of clinically important bacteria isolated from 12 hospitals in Korea in 2005 and 2006, 대한임상미생물학회지 , 2007-03, (국내)기타
  96. Genetic and biochemical characterization of GES-5, an extended-spectrum class A beta-lactamase from Klebsiella pneumoniae., Diagnostic microbiology and infectious disease, 2007-02, (국외)SCI
  97. Quantification of CpG methylation at the 5′-region of XIST by pyrosequencing from human serum, Electrophoresis, 2007-01, (국외)SCI
  98. Roche Modular Analytics E170를 이용한 풍진 특이 IgM 및 IgG 항체 검사의 평가, 임상병리와 정도관리, 2007-01, (국내)기타
  99. Klebsiella pneumo mae isolate producing at least eight different beta-lactamases, including AmpC and KPC beta-lactamases , Antimicrobial agents and chemotherapy, 2007-01, (국외)SCI
  100. In vitro studies with DQ-113 and comparison fluoroquinolones to determine propensities to select resistance in gram-positive cocci., Antimicrobial agents and chemotherapy, 2006-12, (국외)SCI
  101. CTX-M-12, PER-1 및 OXA-30 β-Lactamase 생성 Klebsiella pneumoniae의 출현, 대한임상미생물학회지 , 2006-09, (국내)기타
  102. 성인 급성골수성백혈병에서 저강도 동종 제대혈이식 4예, 대한혈액학회지, 2006-08, (국내)기타
  103. A novel ceftazidime-hydrolysing extended-spectrum β-lactamase, CTX-M-54, with a single amino acid substitution at position 167 in the omega loop , The Journal of antimicrobial chemotherapy, 2006-05, (국외)SCI
  104. Multilocus Sequence Typing of Clonal Changes of Methicillin-resistant Staphylococcus aureus Isolated from Intensive Care Unit Patients: 1996 versus 2004, 대한임상미생물학회지 , 2006-04, (국내)KCI후보
  105. 균혈증 및 요로감염에서 분리된 장구균의 항균제 내성 및 병독성 인자 규명, 대한임상미생물학회지 , 2006-04, (국내)기타
  106. CTX-M-12와 새로운 CTX-M형 Extended-Spectrum -Lactamase 생성 Klebsiella pneumoniae의 출현 , 대한진단검사의학회지, 2006-02, (국내)KCI
  107. 회장 말단부에 궤양을 동반한 혈구탐식증후군 1예, 대한소화기학회지, 2006-02, (국내)KCI
  108. TTP 진단을 위한Fluorescence-quenching substrate를 이용한 새로운ADAMTS-13 활성도 측정법의 유용성, 대한혈액학회지, 2005-12, (국내)KCI
  109. Molecular characterization of vancomycin-resistant enterococci from clinical and surveillance specimens , Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America, 2005-11, (국외)SCI
  110. 박동수, 오도연, 강명서, 안희정, 이선주, 김남근: 전이성 신세포암의 보조 면역치료로써 자가종양백신의 적용, Korean Journal of Urology, 2005-09, (국내)KCI
  111. Novel monoclonal antibody that recognizes new neoantigenic determining D-dimer, Thrombosis research, 2005-07, (국외)SCI
  112. 후천성 혈소판무력증 1예, 대한혈액학회지, 2005-06, (국내)KCI
  113. Influence of combined methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase enhancer region (TSER) polymorphisms to plasma homocysteine levels in Korean patients with recurrent spontaneous abortion, Thrombosis research, 2005-05, (국외)SCI
  114. 변이형 모발상세포백혈병 1례, 대한혈액학회지, 2004-09, (국내)KCI
  115. 급성골수성백혈병의 관해유도 항암화학요법 후 발생한 Trichosporon beigelii 진균혈증, 대한혈액학회지, 2004-06, (국내)KCI
  116. 연령, 임신, 질환에 따른 ADAMTS-13 활성도의 변화, 대한혈액학회지, 2004-06, (국내)KCI
  117. Detection of hepatitis B virus YMDD variants using mass spectrometric analysis of oligonucleotide fragments, Journal of hepatology, 2004-01, (국외)SCI
  118. 객담에서 Multi-drug Resistant Acinetobacter baumannii가 동정된 중환자실 환자에서 Clinical Pulmonary Infection Score의 임상적 유용성 Clinical usefulness of Clinical Pulmonary Infection Scare of ICU Patients with Sputum Culture positive for Multi-drug resistant Acinetobacter baum, Tuberculosis and Respiratory Diseases, 2003-12, (국내)KCI
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